Supply Tightness and Trade Hurdles Push Levocetirizine Dihydrochloride higher in the US

Supply Tightness and Trade Hurdles Push Levocetirizine Dihydrochloride higher in the US

Charles Dickens 29-Dec-2025

The import price scenario within the US market of Levocetirizine Dihydrochloride, one of the most active pharmaceutical ingredients of an antihistamine brand, has been observing a steady rise in prices at a mere 0.25% nominal increase, majorly on a CFR Los Angeles basis. Currently, the import price range has registered a considerable escalation from October to the end of 2025 owing to a series of reasons connected to tariffs, among other factors. Increased US tariffs on APIs imported from China and India, reaching as high as 20% for some products, have also pinched Levocetirizine Dihydrochloride margins, encouraging the increased consumption of the API due to the availability constraint. While tariff relief policies exist temporarily, uncertainty has continued to fuel the purchase of products in the forward market and the building of stocks. Slowdowns in Levocetirizine Dihydrochloride API manufacturing in Asia, together with the seasonality of allergy products, continue the trend of reduced supply and sustained prices.

Selenis has effectively manufactured recycled PET chips using terephthalic acid sourced from Circ®, a textile-to-textile recycler based in Virginia. The chip production took place through a series of batches at Selenis' pilot plant in San-Giorgio, Italy. By utilizing inputs recovered from polycotton textile waste, Selenis has created high-quality PET chip, which has been further processed into DTY yarn. This yarn will play a crucial role in product development as Circ prepares for additional capsule launches. Selenis is leveraging the success of this initial collaboration phase and is committed to advancing towards an offtake partnership to support Circ's inaugural industrial facility. Eduardo Santos, Head of Corporate Strategy at Selenis, remarked that the monomer synthesis showed a performance comparable to virgin terephthalic acid. He expressed optimism about the consistent quality of Circ's monomer output and anticipated future commercial success. Santos pointed out that the Circ partnership complements Selenis's existing mission and goals for a more sustainable textile industry. He further stated their anticipation of expanding upon this collaboration and providing support for Circ's forthcoming commercial production trials.

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